NEURODEVELOPMENT

Regulated tether controls asymmetric cell fate

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Science  02 Mar 2018:
Vol. 359, Issue 6379, pp. 1005-1006
DOI: 10.1126/science.359.6379.1005-e

In the developing fruitfly, the transcription factor Prospero regulates cellular quiescence and fate. Hannaford et al. show how an adaptor protein called Miranda manages Prospero activities through sequestration. During interphase in neuroblasts, Miranda binds directly to lipids of the plasma membrane, keeping Prospero away from the cellular nucleus, where it could incite quiescence. During metaphase, thanks to a key phosphorylation, Miranda instead binds to actin bundles at the basal pole of the cell. Prospero, thus tethered, is delivered to one but not the other of the daughter cells, leading to asymmetric allocation of cellular fate.

eLife 7, e29939 (2018).

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