β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

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Science  02 Mar 2018:
Vol. 359, Issue 6379, pp. 1056-1061
DOI: 10.1126/science.aan4829

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An off switch for helminth immunity

Group 2 innate lymphoid cells (ILC2s) are involved in responses to helminths, viruses, and allergens. Moriyama et al. found that ILC2s interact with the nervous system to modulate helminth immunity. ILC2s from the small intestine expressed the β2-adrenergic receptor (β2AR), which normally interacts with the neurotransmitter epinephrine. Inactivating β2AR resulted in lower helminth burden and more ILC2s, eosinophils, and type 2 cytokine production in mice. Conversely, treatment of helminth-infected mice with a β2AR agonist enhanced worm burden and reduced proliferation of ILC2s. Thus, β2AR negatively regulates ILC2-driven protective immunity.

Science, this issue p. 1056