In DepthBiomedicine

Restraining immunity could lower high blood pressure

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Science  02 Mar 2018:
Vol. 359, Issue 6379, pp. 966-967
DOI: 10.1126/science.359.6379.966

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The immune system is an underappreciated culprit in hypertension. Numerous studies suggest that immune cells increase blood pressure in rodents, and some evidence suggests they do the same in people. Activated immune cells harm the kidneys and the lining of the blood vessels, causing changes that increase blood pressure. In the kidneys, for instance, the cells promote the retention of sodium, which boosts blood pressure. Researchers have identified a compound, 2-HOBA, that curbs immune cells' effects on blood pressure in mice with hypertension. 2-HOBA blocks the effects of oxidized lipids that can damage proteins and activate immune cells. Researchers hope to begin a clinical trial of the compound in people.