Speed representation in the brain

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Science  09 Mar 2018:
Vol. 359, Issue 6380, pp. 1115-1116
DOI: 10.1126/science.359.6380.1115-b

Speed- and direction-responsive neurons in the medial entorhinal cortex and the hippocampus form a major component of the mammalian space representation system. There are long-range GABAergic projections between these two brain regions. Some of these inputs originate from parvalbumin-expressing inhibitory neurons. However, it has not been shown whether the parvalbumin cells projecting to the hippocampus are speed cells. Ye et al. used extracellular recording, optogenetic tagging, and immunohistochemistry to investigate whether, and how, speed-responsive cells in the entorhinal cortex and hippocampus are functionally connected. The majority of medial entorhinal speed cells were fast-spiking, the hippocampus received direct input from such cells, and GABAergic long-range projections to the hippocampus originated almost exclusively from parvalbumin-positive neurons. This indicates that hippocampus-projecting speed cells are part of this subpopulation.

Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1720855115 (2018).

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