TUMOR IMMUNOLOGY

Tumor sensing by the immune system

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Science  16 Mar 2018:
Vol. 359, Issue 6381, pp. 1228-1229
DOI: 10.1126/science.359.6381.1228-e

The idea that innate lymphoid cells (ILCs) play a role in cancer is of interest because these immune cells respond to IL-33, a cytokine proposed to regulate cancer development. Saranchova et al. report that the subgroup called ILC2s may limit tumor growth rate and metastasis. In a mouse model engineered to lack ILC2s, lung cancer cells implanted into the leg enlarged more rapidly than in mice expressing ILC2s. Moreover, in the absence of ILC2, cancer cells spread to other tissues, including the lung, brain, and adrenal gland. The authors propose that IL-33 released by the cancer cells locally stimulates ILC2s, which in turn produce other cytokines that promote an immune response to cancer, limiting its growth and spread.

Sci. Rep. 10.1038/s41598-018-20608-6 (2018).

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