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Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

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Science  16 Mar 2018:
Vol. 359, Issue 6381, pp. 1247-1250
DOI: 10.1126/science.aao6595

Article Information

vol. 359 no. 6381 1247-1250

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History: 
  • Received for publication August 12, 2017
  • Accepted for publication January 30, 2018

Author Information

  1. Min Dong1,
  2. Venkatesan Kathiresan2,
  3. Michael K. Fenwick1,
  4. Andrew T. Torelli1,
  5. Yang Zhang1,
  6. Jonathan D. Caranto1,
  7. Boris Dzikovski1,
  8. Ajay Sharma2,
  9. Kyle M. Lancaster1,
  10. Jack H. Freed1,
  11. Steven E. Ealick1,*,
  12. Brian M. Hoffman2,*,
  13. Hening Lin1,3,*
  1. 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
  2. 2Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
  3. 3Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
  1. *Corresponding author. Email: see3{at}cornell.edu (S.E.E.); bmh{at}northwestern.edu (B.M.H.); hl379{at}cornell.edu (H.L.)

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