Metabolism

Refining diabetes into five types

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Science  06 Apr 2018:
Vol. 360, Issue 6384, pp. 45-46
DOI: 10.1126/science.360.6384.45-b

Diabetes has traditionally been classified as either type 1 or type 2. Ahlqvist et al. analyzed nearly 15,000 Scandinavian patients to refine the conventional diabetes classification system. Using six biological parameters and phenotype-based clustering, the researchers found that patients were stratified into five subgroups. These subgroups differed in genetic associations, disease progression, and medical outcomes. For example, individuals in the insulin-deficient subgroup were more susceptible to developing retinopathy. In contrast, the patients who were most resistant to insulin were more prone to developing diabetic kidney disease than other subgroups. Updating the diabetes classification may help predict and assist those patients at greatest risk for complications and improve personalized care.

Lancet Diabetes Endocrinol. 10.1016/S2213-8587(18)30051-2 (2018).

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