Genomics

Denisovans shaped our genomes, twice

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Science  13 Apr 2018:
Vol. 360, Issue 6385, pp. 167-168
DOI: 10.1126/science.360.6385.167-d

Studies of “molecular relics” from archaic humans in modern human genomes have shown that independent interbreeding events occurred between the ancestors of Eurasians and the Neandertals and Denisovans. Because these archaic admixtures happened after the out-of-Africa migration of the modern human ancestors, comparing present-day non-African and African genomes can reveal introgression events without the need for an archaic reference genome. Using this approach, Browning et al. found evidence for two pulses of gene flow from distinct Denisovan populations into modern humans in East Asian and Papuan genomes. These findings point to at least two populations of Denisovans that contributed genes to modern humans.

Cell 173, 53(2018).

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