PerspectiveHypothesis

A unifying concept in vascular health and disease

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Science  20 Apr 2018:
Vol. 360, Issue 6386, pp. 270-271
DOI: 10.1126/science.aat3470

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Summary

Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. But is this really the case? An evaluation of the literature suggests that unresolved vascular remodeling may be a key element of virtually all vascular diseases. This commonality raises the possibility of unifying principles that govern vascular remodeling and the possibility that methods to restore normal remodeling could effectively treat multiple disease states.