CANCER

Even more genes control cell growth

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Science  20 Apr 2018:
Vol. 360, Issue 6386, pp. 281-282
DOI: 10.1126/science.360.6386.281-g

A full understanding of cancer evolution needs a systematic approach. Screening for genes that drive unrestrained proliferation of human cells could answer questions about the relative roles of mutations, gene dose, and tissue specificity in cancer development. To find those for which dosage changes could promote or inhibit cell proliferation, Sack et al. screened 16,000 genes in mammary, fibroblast, and pancreatic cells. They found nearly 400 genes that drove cell growth and more than 1000 that suppressed proliferation. Many expected genes that control the cell cycle were detected, but most of the identified genes were not previously known to regulate proliferation. Alterations in the somatic copy number of these genes in cancers indicate that they may contribute to tumorigenesis. Proliferation control depended strongly on cell type. Specific genetic-network architecture may be created during development in different cell types, perhaps through epigenetic control.

Cell 10.1016/j.cell.2018.02.037 (2018).

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