Molecular Biology

Stress granule transcription

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Science  11 May 2018:
Vol. 360, Issue 6389, pp. 616
DOI: 10.1126/science.360.6389.616-b

When translation initiation is stalled under stress, nontranslating messenger ribonucleoproteins form insoluble assemblies called stress granules (SGs) in the cytosol. Namkoong et al. sequenced all transcripts from purified SGs. They found that although translation of most transcripts is inhibited, only a subset of transcripts form SGs. The length and abundance of the AU-rich elements are key features determining SG-targeting specificity, agreeing with a recent report by Van Treeck et al. showing that RNA self-assembly drives SG formation. SGs have been implicated in cancer and neurodegenerative diseases; understanding the specificity of their RNA components and the principles of their formation offers insights into their pathological contribution.

Mol Cell. 10.1016/j.molcel.2018.02.025; Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1800038115 (2018).

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