Infectious Diseases

Mycobacteria and metabolism

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Science  18 May 2018:
Vol. 360, Issue 6390, pp. 748
DOI: 10.1126/science.360.6390.748-b

Since the discovery of Mycobacterium tuberculosis more than a century ago, great progress has been made in defining mechanisms of host resistance to tuberculosis (TB). In contrast, our understanding of how 90 to 95% of infected individuals live with chronic TB is extremely limited. Tzelepis et al. examined the role of mitochondrial matrix protein cyclophilin D (CypD) in T cells by using a mouse model of M. tuberculosis infection. CypD-deficient mice were more susceptible to infection, despite enhanced M. tuberculosis–specific T cell responses. Specific T cells apparently had no impact on curbing bacterial loads but did substantially increase lung immunopathology.

Sci. Immunol. 3, eaar4135 (2018).

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