Circadian Regulation

Timing metabolism in human muscle

See allHide authors and affiliations

Science  18 May 2018:
Vol. 360, Issue 6390, pp. 749-750
DOI: 10.1126/science.360.6390.749-b

Circadian rhythms are driven by intrinsic biological clocks that regulate and coordinate activity and metabolism. Skeletal muscle is fueled by glucose, but if glucose sensing by the skeletal muscle clock is disrupted, metabolic disease can result. Perrin et al. used genome-wide transcription analysis to investigate clock-controlled circadian transcription in skeletal muscle and myotubes in vitro. Human biopsy samples exhibited rhythmic transcription, which occurred in two phases: Immune response genes were transcribed early in the day, whereas muscle contraction genes were expressed in the afternoon. In the absence of a fully functional clock, expression patterns of genes related to insulin response, myokine secretion, and lipid metabolism were strongly affected.

eLife 10.7554/eLife.34114 (2018).

Navigate This Article