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Science  18 May 2018:
Vol. 360, Issue 6390, pp. 806
DOI: 10.1126/science.360.6390.806

Glass Vial Deep-Well Plate

The new glass vial deep-well plate from Porvair Sciences is designed to ensure that absolutely no extractables or leachates are present in a withdrawn sample, thereby removing the risk of false peaks in sensitive UHPLC and mass spectrometry applications. This product combines 1 mL × 96 tapered- or flat-bottomed glass vials held firmly in each well of a 2 mL × 96 deep-well plate. These plates are less costly than solid glass plates and are precisely manufactured to comply with ANSI/SLAS dimensions, to ensure complete compatibility with automated equipment. Complimented by a snug-fitting silicone cap mat that seals each vial individually with a prescored septum, the glass vial deep-well plates allow an autosampler to pierce each septum and withdraw sample from each sealed vial with high precision and reproducibility.

siRNA Kit

The Trilencer-27 siRNA kit contains Dicer–Substrate duplexes that provide two critical improvements over the use of traditional 2-mer small interfering RNA (siRNA) designs. 27-mer siRNA takes advantage of the natural processing by Dicer, producing 10-fold higher potency and specificity than shorter 21-mer RNA interference (RNAi) forms. 27-mer siRNA duplexes also evade the radar of the mammalian interferon response when expressed in mammalian cells, and initiate strong, specific gene silencing. Because of its optimal design, 27-mer siRNA has the assets of improved efficacy and minimal interferon response. The kit, which comes with three gene-specific siRNAs and one negative control, provides genome-wide coverage against human, mouse, and rat messenger RNA. It guarantees greater than 70% gene knockdown.

IDO Pathway Research Products

AMS Biotechnology (AMSBIO) offers numerous IDO pathway research (IDO1, IDO2, and TDO genes) products. Researchers are trying to identify the complex mechanisms that enable cancer cells to evade the host's immune system. Cancer cells use the indoleamine 2,3-dioxygenase (IDO) pathway to suppress the host's immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells. The IDO pathway is active in many tumors, providing a direct defense against T-cell attack. It is also active in many antigen-presenting cells, resulting in peripheral tolerance to tumor-associated antigens. AMSBIO offers Inhibitor Screening Assay Kits designed to measure IDO1, IDO2, and TDO enzyme inhibition. In addition, the company has stable recombinant HEK293 cell lines for monitoring IDO1 and TDO pathway activity, and screening for activators or inhibitors of IDO1 and TDO. For studying enzyme kinetics, substrate specificity, and screening inhibitors, AMSBIO also offers human and mouse IDO1, IDO2, and TDO His-tagged proteins.

CRISPR/Cas9 Mouse Model Generation Services

While it's tempting to try to save costs by doing it yourself, generating a new mouse model using CRISPR comes with many challenges that are sometimes unpredictable. These can lengthen a simple knockout project by several months if not managed correctly. By letting the Jackson Laboratory (JAX) take the hassle out of generating your new mouse strain, you enable your lab staff to focus on more important things, like performing experiments and getting papers published. There is no need to backcross your new model to make it congenic. We can generate the model you need on the genetic background you want. We've generated models in a variety of strain backgrounds, including BALB/cJ, C57BL/6J, C57BL/6NJ, FVB/NJ, NOD/ShiLtJ, and NSG, and are adding new strains regularly. From conditional knockouts to reporter insertions and difficult genetic backgrounds, JAX has 80-plus years' experience generating complex models. Save time and money by letting the experts build your model in the most efficient way possible.

  • The Jackson Laboratory

  • For info: 800-422-6423

  • www.jax.org

Network Analyzer

The DIRIS Q800 network analyzer boasts unparalleled quality compared to other analyzers on the European market, and is IEC 62586-2 Class A certified. The electrical energy that powers a network or facility is subject to pollution or interference stemming from a variety of sources. This interference can have severe consequences for sensitive equipment connected to the network, and can sometimes cause outages that adversely affect the operation of critical facilities, including industrial production lines, data centers, infrastructures, health care centers, and more generally, lighting and safety systems in public-access buildings, among others. The analyzer identifies the sources of failure before they reach a critical point for the application, so that any potential preventive maintenance operations can be performed in time to guarantee availability of the required electric power. Besides anticipating power failures, the DIRIS Q800 optimizes the power facility as part of an energy-efficiency initiative. 

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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