Physiology

How drinking (alcohol) affects drinking (water)

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Science  25 May 2018:
Vol. 360, Issue 6391, pp. 871-872
DOI: 10.1126/science.360.6391.871-e

The hormone FGF21 (fibroblast growth factor 21) is a major regulator of drinking in mice. FGF21 is produced in the liver and links metabolic status to behavioral responses through actions in the brain. It has many effects on metabolism, including regulation of preference for sugar consumption. Song et al. found that various stresses, such as alcohol consumption or a ketogenic diet, caused increased production of FGF21 and stimulation of water drinking. Although alcohol consumption has well-known acute effects on water balance through inhibition of antidiuretic hormone action, this work shows an important role for FGF21 in stimulating water drinking after alcohol consumption. FGF21 can even suppress preference for alcohol consumption in favor of pure water.

Cell Metab. 10.1016/j.cmet.2018.04.001 (2018).

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