RNA processing for metabolic control

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Science  15 Jun 2018:
Vol. 360, Issue 6394, pp. 1199-1200
DOI: 10.1126/science.360.6394.1199-d

Autophagy is a cellular response to nutrient starvation that allows cells to recycle existing molecules and organelles. Tang et al. investigated the mechanisms by which TORC1 (target of rapamycin complex 1) regulates autophagy. They discovered that regulation occurs through control of RNA processing. Using a genetic screen in fruitflies, they pinpointed the CPA (cleavage and polyadenylation) complex as the regulator of autophagy. CPA in turn regulates polyadenylation and alternative splicing of RNAs encoding the key proteins that regulate autophagy. This control appears to be conserved in mammalian cells, too: Loss of a component of the CPA complex disrupted regulation of metabolism and autophagy in cultured human cells.

Cell Metab. 10.1016/j.cmet.2018.02.023 (2018).

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