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Science  15 Jun 2018:
Vol. 360, Issue 6394, pp. 1255
DOI: 10.1126/science.360.6394.1255-a

Laser Scanner

The Sapphire Biomolecular Imager is a next-generation laser scanner featuring near infrared (NIR) and visible wavelengths (red, green, blue) fluorescent, true chemiluminescent, and phosphor imaging down to 10-μm resolution. This flexibility and performance is achieved by the unique combination of four solid-state laser diodes and three different detection methods: photomultiplier tubes, avalanche photodiodes, and a cooled CCD camera. Coupled with easy-to-use software, the Sapphire allows for rapid image capture, analysis, and quantification across a wide range of proteomics techniques (quantitative NIR Western blots, visible fluorescent imaging, chemi-luminescent Western blots, and phosphor imaging), all within a single compact footprint.

Cloud-Connected Pipette and Electronic Lab Notebook

Gilson Connect is a cloud-connected platform that powers a product line of Bluetooth-enabled, smart liquid–handling devices designed to help scientists achieve verifiable science. It includes TRACKMAN Connected, an all-in-one kit that includes a tablet with the PipettePilot tracker application, and PIPETMAN M Connected, a Bluetooth-enabled, smart electronic pipette. Gilson Connect devices can record and track pipette performance in real-time and transmit data to sciNote, a free, open-source electronic lab notebook. Researchers can check their pipetting data to detect any errors resulting from improper use of the pipette, thereby improving traceability and experiment reproducibility. Environmental sensors connected wirelessly to this tablet also enable researchers to monitor environmental conditions that can affect pipetting accuracy. By partnering with sciNote, Gilson Connect allows researchers to store data and consolidate records in a secure location that is easily accessible and shareable, effectively eliminating lost data, a significant contributor to the irreproducibility crisis.

Multiplex ELISA Array

Quantibody is an array-based, multiplex ELISA system for simultaneous quantitative measurement of multiple cytokines, growth factors, proteases, soluble receptors, and other proteins in a wide variety of sample types. It combines a high specificity and sensitivity of ELISA with the high throughput of the glass chip–based array. With this platform, only 50 µL of sample is needed for quantification of up to 40 proteins in quadruplicate (0.5 mL for the 400-target Quantibody array), making this array 80 times more efficient than traditional ELISA.

Orthogonal Platform

Postnova Analytics has integrated its AF2000 MultiFlow Field-Flow Fractionation (FFF) platform with its SC2000 modular multidetector size-exclusion chromatography (SEC) system, creating an advanced orthogonal design that allows both FFF and SEC separations to be carried out on the same sample within one instrument. The result is enabling labs worldwide to generate more useful information from even complex proteins, antibodies, polypeptides, and polysaccharides. As both separation techniques in the Postnova 2000 Series FFF/SEC system can use the same optimized detector set—ultraviolet, refractive index, and multiangle light scattering—the system's enhanced applications potential is achieved with minimal redundancy, using an automatic switching value and software upgrade kit. The system can be run with different eluents, pH, and wide-ranging temperature conditions, making it ideal for the characterization of natural or synthetic macromolecules.

Modular Membrane Chromatography

Sartorius Stedim Biotech has expanded its range of single-use membrane chromatography solutions with Sartobind cassettes, which enable large-scale, bind-and-elute membrane chromatography for large proteins such as viruses and virus-like particles, protein conjugates, and blood factors. Sartobind cassettes offer the same flow path, bed heights (4 mm and 8 mm), and void-volume ratios as Sartobind capsules, and are compatible with Q, S, STIC PA (primary amine), and phenyl ligands. Multiple cassettes, each with 0.8-L or 1.6-L membrane volume, can be set up in three different stainless-steel holders, resulting in maximum membrane volumes of 20 L, 50 L, or 100 L. Pressure-flow performance and the shape of breakthrough curves are identical to those found in the smaller capsule sizes, independent of the number of cassettes used. Setup takes only minutes, even at manufacturing scale, whether for capture applications or flow-through removal of process contaminants. 

Lab Automation Scheduling Software

Cellario system control software allows integration with a wide variety of components and liquid handlers, making it easy to add or subtract them from their automated platforms. This unique lab scheduling software architecture enables HighRes Biosolutions to tightly integrate Cellario with your laboratory information management system (LIMS) or other internal software. If needed, HighRes can even create custom laboratory scheduling software for your more complex processes and assays (or lab data output capturing requirements). Total system power loss can be overcome in just a few clicks. Our instrument device driver software is tailor-made for each device we integrate, and can detect and report most errors back to Cellario—which can then be configured to automatically react to them. Cellario protocols can be modified on the fly, even in the middle of a run, using the Active Plate Editor feature.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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