Locally coordinated synaptic plasticity of visual cortex neurons in vivo

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Science  22 Jun 2018:
Vol. 360, Issue 6395, pp. 1349-1354
DOI: 10.1126/science.aao0862

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Rebalancing strength between synapses

Activation of a neuronal pathway is often associated with inhibition of surrounding pathways. How locally coordinated synaptic plasticity occurs in vivo is not known, nor is its role in shaping neuronal responses. El-Boustani et al. paired optogenetic stimulation of single neurons with a visual input and were able to shift the neuron's receptive field toward the target location. Spines that expressed structural long-term potentiation had receptive fields overlapping the target stimulus but were surrounded by spines that expressed receptive fields away from the target.

Science, this issue p. 1349