Epigenetics, aging, and glycolysis

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Science  06 Jul 2018:
Vol. 361, Issue 6397, pp. 39-40
DOI: 10.1126/science.361.6397.39-f

Aging brings reduced fitness and increased incidence of disease and death. Epigenetic changes are thought to be associated with various aging processes. By using CRISPR-Cas9 mutagenesis in the model fly, Drosophila, Ma et al. found that aging was associated with a loss of fidelity in histone modifications mediated by Polycomb proteins—specifically, a reduction in the repressive epigenetic mark called H3K27me2/3. If the Polycomb protein PRC2 was mutated, H3K27me2/3 was lost, glycolysis was elevated, and life span was restored. Transgenically increasing gene dosage for glycolytic enzymes also promoted life span, locomotion, and resistance to oxidative stress.

eLife 10.7554/eLife.35368 (2018).

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