Contents
06 July 2018
Vol 361, Issue 6397
Vol 361, Issue 6397
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Polio outbreaks in the DRC threaten eradication effort
Vaccine-derived virus spreads despite emergency response
- Lawmakers ask NIH and CDC charities for more on donors
Congressional panel seeks greater transparency on private donations to foundations that aid federal research
- Optical interferometers sharpen views of the sky
In New Mexico, a renewed attempt to build an optical array could bring spy satellites into focus
- Biologists raise alarm over changes to biopiracy rules
Plan would bring genetic sequences under Nagoya Protocol
- Proposed DOE test reactor sparks controversy
Congress favors the Versatile Fast Neutron Source but some scientists see little need
Feature
- Hidden conflicts?
An investigation finds a pattern of after-the-fact compensation by pharma to those advising the U.S. government on drug approvals
- Is FDA's revolving door open too wide?
Many FDA staff overseeing drug reviews end up working for makers of those drugs
Working Life
Letters
Books et al.
Policy Forum
- Autonomous vehicles: No driver…no regulation?
Driverless cars are on the road with no federal regulation, and the public is paying the price
Perspectives
- America's lost dogs
The dogs that arrived in the Americas with human settlers ∼10,000 years ago left almost no genetic traces
- A new brain circuit in feeding control
Components of a neural circuit that regulates body weight are found
- Molecular movies filmed at conical intersections
Electron diffraction maps atomic motions that result from photoexcitation of CF3I molecules
- The search for ancient DNA heads east
Multiple migrations explain the peopling of Southeast Asia in the past 10,000 years
- Chromatin domains rich in inheritance
Only certain histone posttranslational modifications qualify as being epigenetic
- The dynamic art of growing COF crystals
Growth modulation leads to large, high-quality covalent organic framework crystals
Research Articles
- Structure basis for RNA-guided DNA degradation by Cascade and Cas3
Structures of pre– and post–DNA-nicking states of the Type I-E CRISPR Cascade/Cas3 complex reveal mechanisms of target degradation.
- Atmospheric blocking as a traffic jam in the jet stream
Waves in the jet stream reveal the close similarity between atmospheric blocking and traffic congestion on a highway.
Reports
- Single-crystal x-ray diffraction structures of covalent organic frameworks
The addition of aniline enables the growth of single crystals of imine-based covalent organic framework materials.
- Seeded growth of single-crystal two-dimensional covalent organic frameworks
Micrometer-scale single crystals of two-dimensional boronate ester–linked frameworks can be grown in a two-step process.
- A single-photon switch and transistor enabled by a solid-state quantum memory
A solid-state quantum dot memory is used to realize a single-photon switch and optical transistor.
- Observation of an environmentally insensitive solid-state spin defect in diamond
The neutral charge state of silicon vacancy centers in diamond shows promising quantum information properties.
- Imaging CF3I conical intersection and photodissociation dynamics with ultrafast electron diffraction
Electron diffraction reveals the interplay of electronic and nuclear motion during light-induced scission of a C–I bond.
- Tandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes
Cobalt catalyzes successive addition of two equivalents of ethylene to enynes to form chiral cyclobutane products.
- Biological uptake and reversible scavenging of zinc in the global ocean
The distribution of zinc in the world oceans depends on circulation, organic matter cycling, and reversible scavenging.
- Regulation of feeding by somatostatin neurons in the tuberal nucleus
A clearly defined group of neurons in an area of the hypothalamus plays a central role in the control of feeding.
- The evolutionary history of dogs in the Americas
Ancient North American dogs survive primarily as a canine transmissible venereal tumor.
- Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
Ancient goat genomes elucidate a dispersed domestication process across the Near East.
- The prehistoric peopling of Southeast Asia
Ancient genomes reveal four layers of human migration into Southeast Asia.
- Ancient genomes document multiple waves of migration in Southeast Asian prehistory
Ancient DNA data shed light on the past 4000 years of Southeast Asian genetic history.
Erratum
About The Cover
COVER An analysis of pharmaceutical payments to physicians after they voted on drug approval recommendations suggests that the Food and Drug Administration (FDA) needs to consider whether prospects of future rewards could influence its advisory panels. The investigation also indicates that the FDA may have missed more traditional conflicts of interest for those advisers. Another story looks at revolving-door concerns for FDA staff. See p. 16.
ILLUSTRATION: STEPHAN SCHMITZ