CANCER

Finding the precise drug

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Science  13 Jul 2018:
Vol. 361, Issue 6398, pp. 142
DOI: 10.1126/science.361.6398.142-c

Treating cancer according to the molecular makeup of tumor cells is challenging. How can we find a target that will kill tumor cells and match it to an effective drug? Alvarez et al. analyzed the protein-signaling networks in human gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to find master regulators of tumor survival. Subsequent screening of GEP-NET–derived cells with various drugs confirmed that their top hit, entinostat, inhibited GEP-NET growth in vivo. This approach has the potential to provide unbiased precision therapy for many cancers, especially rare cancers, such as GEP-NETs.

Nat. Genet. 10.1038/s41588-018-0138-4 (2018).

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