Research Article

Programming self-organizing multicellular structures with synthetic cell-cell signaling

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Science  13 Jul 2018:
Vol. 361, Issue 6398, pp. 156-162
DOI: 10.1126/science.aat0271

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Engineering multilayered cellular structures

The ability to program the manufacture of biological structures may yield new biomaterials or synthetic tissues and organs. Toda et al. engineered mammalian “sender” and “receiver” cells with synthetic cell surface ligands and receptors that controlled gene regulatory circuits based on Notch signaling. Programming the cells to express cell adhesion molecules and other regulatory molecules enabled spontaneous formation of multilayered structures, like those that form during embryonic development. The three-layered structures even showed regeneration after injury.

Science, this issue p. 156