DNA METHYLATION

Differential methylation affects risk of MS

See allHide authors and affiliations

Science  20 Jul 2018:
Vol. 361, Issue 6399, pp. 241-242
DOI: 10.1126/science.361.6399.241-e

Specific variants of the human leukocyte antigen (HLA) locus are heritable risk factors for the autoimmune disease multiple sclerosis (MS). However, how these variants confer risk is not well understood. It has been proposed that epigenetic modifications, such as differences in methylation, of noncoding regions near the HLA coding regions may explain why some people are more likely to develop MS. Comparing controls and patients, Kular et al. identified hypomethylated genomic regions associated with increases in gene expression at the HLA locus that increased the risk of developing MS. Extending this investigation, the authors identified a protective variant that reduces the probability of developing MS that is more highly methylated.

Nat. Commun. 10.1038/s41467-018-04732-5 (2018).

Navigate This Article