Neutrophils take a different tack

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Science  27 Jul 2018:
Vol. 361, Issue 6400, pp. 376-377
DOI: 10.1126/science.361.6400.376-f

Antibody-dependent cellular cytotoxicity is an important process by which cancer cells can be targeted and killed. Immune cells, such as T and NK (natural killer) cells, express Fc receptors that recognize cancer cells coated with antibodies. They then release cytotoxic granules that result in apoptosis. Matlung et al. show that neutrophils induce antibody-dependent cellular cytotoxicity via a completely different mechanism. This process entails trogocytosis-induced lysis of tumor cells, which the authors term “trogoptosis.” They find that neutrophils endocytose cytoplasmic fragments of target cells, which induces cancer cell necroptosis. In addition to direct killing, this mechanism may be important for the release of cancer neoantigens and damage-associated molecular patterns, which further activate and direct the immune response to tumors.

Cell Rep. 23, 3946 (2018).

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