Metabolism

High fat promotes overeating

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Science  10 Aug 2018:
Vol. 361, Issue 6402, pp. 565-566
DOI: 10.1126/science.361.6402.565-d

Disagreement abounds over what constitutes a healthy diet and which components might provoke overeating and obesity in human populations. Hu et al. took a systematic approach to the latter question by feeding mice diets that differed in their proportion of fat (from 8 to 80%), protein (from 5 to 30%), carbohydrate (from 10 to 80%), or sucrose (from 5 to 30%). The only mice that ate more than they needed and became overweight were those eating a diet high in fat content. Furthermore, high-fat diets stimulated hedonic or reward pathways in the brain, as measured by gene expression. Because an equivalent comparison in humans would require a decade of study, we are unlikely to know how closely the results would be replicated in people.

Cell Metab. 10.1016/j.cmet.2018.06.010 (2018).

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