Research Article

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS

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Science  10 Aug 2018:
Vol. 361, Issue 6402, eaar6236
DOI: 10.1126/science.aar6236

Article Information

vol. 361 no. 6402

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History: 
  • Received for publication December 1, 2017
  • Accepted for publication May 15, 2018

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Author Information

  1. Shishi Lin1,
  2. Sergei Dikler2,
  3. William D. Blincoe3,
  4. Ronald D. Ferguson1,
  5. Robert P. Sheridan4,
  6. Zhengwei Peng4,
  7. Donald V. Conway5,
  8. Kerstin Zawatzky3,
  9. Heather Wang3,
  10. Tim Cernak6,*,
  11. Ian W. Davies7,,
  12. Daniel A. DiRocco7,
  13. Huaming Sheng3,,
  14. Christopher J. Welch3,,§,||,
  15. Spencer D. Dreher1,
  1. 1Chemistry Capabilities Accelerating Therapeutics, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
  2. 2Bruker Daltonics, Inc., Billerica, MA 01821, USA.
  3. 3Analytical Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
  4. 4Modeling and Informatics, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
  5. 5Discovery Sample Management, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
  6. 6Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115 USA.
  7. 7Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
  1. Corresponding author. Email: huaming.sheng{at}merck.com (H.S.); christopher{at}welchinnovation.com (C.J.W.); spencer_dreher{at}merck.com (S.D.D.)
  • * Present address: Department of Medicinal Chemistry, Department of Chemistry, Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.

  • Present address: Princeton Catalysis Initiative, Princeton University, Princeton, NJ 08544, USA.

  • § Present address: Indiana Consortium for the Analytical Sciences, Indianapolis, IN 46202, USA.

  • || Present address: Welch Innovation, LLC, Cranbury NJ 08512, USA.

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Article usage: May 2018 to February 2019

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May 20183737278531
Jun 20184593334822
Jul 20182455153243
Aug 2018723525931678
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Oct 2018294258153
Nov 2018238217110
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Feb 20191207078