Review

Emerging applications for DNA writers and molecular recorders

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Science  31 Aug 2018:
Vol. 361, Issue 6405, pp. 870-875
DOI: 10.1126/science.aat9249

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Abstract

Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo DNA writing, have opened new avenues for investigating and engineering biology. This Review surveys these technological advances, outlines their prospects and emerging applications, and discusses the features and current limitations of these technologies for building various genetic circuits for processing and recording information in living cells.

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