Research Article

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

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Science  07 Sep 2018:
Vol. 361, Issue 6406, eaan8821
DOI: 10.1126/science.aan8821

Article Information

vol. 361 no. 6406

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  • Received for publication June 1, 2017
  • Resubmitted June 4, 2018
  • Accepted for publication July 17, 2018

Author Information

  1. Se Hoon Choi1,
  2. Enjana Bylykbashi1,
  3. Zena K. Chatila1,*,
  4. Star W. Lee2,,
  5. Benjamin Pulli3,
  6. Gregory D. Clemenson2,,
  7. Eunhee Kim1,
  8. Alexander Rompala1,
  9. Mary K. Oram1,
  10. Caroline Asselin1,
  11. Jenna Aronson1,§,
  12. Can Zhang1,
  13. Sean J. Miller1,||,
  14. Andrea Lesinski1,,
  15. John W. Chen3,
  16. Doo Yeon Kim1,
  17. Henriette van Praag4,
  18. Bruce M. Spiegelman5,
  19. Fred H. Gage2,
  20. Rudolph E. Tanzi1,#
  1. 1Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  2. 2Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  3. 3Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. 4Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA.
  5. 5Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  1. #Corresponding author. Email: tanzi{at}
  • * Present address: Department of Neuroscience, Columbia University, New York, NY 10036, USA.

  • Present address: Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA 92521, USA.

  • Present address: Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.

  • § Present address: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

  • || Present address: Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA.

  • Present address: Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA.


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Article usage: September 2018 to February 2019

Sep 20181712867643980
Oct 2018346514691023
Nov 20181435887551
Dec 20181021566329
Jan 2019921563324
Feb 2019621334182