LONGEVITY

Fasting to improve health span

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Science  28 Sep 2018:
Vol. 361, Issue 6409, pp. 1351-1352
DOI: 10.1126/science.361.6409.1351-g

Patterns of eating, as well as caloric content, are important determinants of health span. Mitchell et al. investigated how dietary composition and feeding patterns influence longevity in a large cohort of mice over 54 weeks. Caloric restriction (a 30% reduction in daily intake) or single-meal feeding (resulting in fasting during each day but no caloric restriction) increased life span and delayed the onset of age-associated pathologies in mice compared with ad libitum feeding. It is possible that daily fasting, even without caloric restriction, may improve health span in humans.

Cell Metab. 10.1016/j.cmet.2018.08.011 (2018).

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