Neuroscience

Memory recirculation and integration

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Science  12 Oct 2018:
Vol. 362, Issue 6411, pp. 195-196
DOI: 10.1126/science.362.6411.195-g

Hippocampal pattern separation minimizes interference between experiences and is critical to episodic memory (a person's collection of memories of an event). However, the hippocampus is also critical for the integration of information across episodes. These two roles are apparently in conflict. Using high-resolution brain scanning, Koster et al. investigated information flow through the layers of the entorhinal cortex that are the inputs and outputs of the hippocampus. Rather than the output of the system being the end product of hippocampal processing, it is recirculated as a new input. This result indicates big-loop recurrence, predicted by computational theories, which states that episodic memory and the integration of information across experiences need not conflict.

Neuron 99, 1342 (2018).

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