Contents
12 October 2018
Vol 362, Issue 6411
Vol 362, Issue 6411
Special Issue
Brain Development
Introduction to special issue
News
- A fragile existence
Why is a remote Colombian town a hot spot of an inherited intellectual disability?
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Leaks put Italy's underground lab in jeopardy
Prosecutors charge Gran Sasso chiefs after chemical spills put spotlight on water safety.
- NASA's next Mars rover aims to explore two promising sites
2020 rover could start with a river delta in Jezero crater.
- Replumbing the lymphatic system
Clinical trials for lymphedema begin to test approaches to restore lymph flow.
- Protein evolution earns chemistry Nobel
Darwinian principles applied to biomolecules led to new drugs, fuels, and detergents.
- DNA printers poised to jump from paragraphs to pages
Enzymes that write DNA could turbocharge synthetic biology and data storage.
Feature
- A new leaf
A decade ago, France launched an ambitious effort to cut pesticide use by half. It failed. Now, the country is trying again.
- Vive la resistant vines!
Disease-resistant varieties could eliminate much of winemakers' need for fungicides.
Working Life
Letters
Books et al.
- The persistence of polio
Inspired by the successful eradication of smallpox, efforts to eliminate poliovirus haven't achieved the same success
- A Nobel laureate in exile
The life and legacy of Muhammad Abdus Salam come into focus in a new film
Essays on Science and Society
- Circuits for care
A small population of hypothalamic neurons orchestrates parenting behaviors
- Building blocks of the human brain
Area-specific excitatory neuron subtypes emerge before sensory experience
- The effortless custody of automatism
Differentially controlled dopamine signaling in the striatum may be critical to habit formation
Policy Forum
- Return of results and data to study participants
A recent report urges progress but builds barriers to research participants' access
Perspectives
- An alternative urban green carpet
How can we move to sustainable lawns in a time of climate change?
- Next-generation self-healing materials
Adjusting molecular structure tackles a long-standing problem of synthetic material longevity
- Dimerization quality control via ubiquitylation
A specialized ubiquitin ligase enzyme approves only functional dimers
- A common trick for transferring bacterial DNA
A known virus-mediated process spreads bacterial genes more than expected
- Treg cells—the next frontier of cell therapy
Will regulatory T cells be a frontline therapy for autoimmunity and other diseases?
- Anti-CRISPRs on the march
The diversity of anti-CRISPR proteins encoded by viruses is rapidly expanding
- Easy access to elusive radical reactions
Two mild approaches generate radical intermediates from masked aldehydes
Research Articles
- Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
Genomic biomarkers will help to elucidate which cancer patients will benefit from PD-1 blockade immunotherapy.
- Thyroid hormone signaling specifies cone subtypes in human retinal organoids
Human retinal organoids offer an opportunity to study the pathways regulating development of color vision.
- Structure and dynamics of the yeast SWR1-nucleosome complex
The yeast nucleosome remodeler SWR1 complex interacts with nucleosomes and induces conformational changes in the DNA wrap.
- Dimerization quality control ensures neuronal development and survival
A quality control system ensures functional dimerization of a widespread protein interaction module by eliminating nonfunctional assemblies.
- A hot and fast ultra-stripped supernova that likely formed a compact neutron star binary
An unusual core-collapse supernova appears to have formed a binary neutron star in a tight orbit.
- Genome hypermobility by lateral transduction
Staphylococcus aureus phages amplify and package while chromosomally integrated such that host DNA becomes incorporated in the virus particle.
Reports
- Entropy-driven stability of chiral single-walled carbon nanotubes
Modeling the interface of carbon nanotubes with their seeding catalyst nanoparticle reveals the origin of their chirality.
- Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates
A phosphorus-based acid catalyst envelops its substrate to form just one carbon-carbon bond selectively.
- Key-and-lock commodity self-healing copolymers
Commodity monomers are combined via a simple and scalable copolymerization to form self-healing polymers.
- Ketyl radical reactivity via atom transfer catalysis
Adding acetyl iodide across carbonyls offers easy access to ketyls via transient I atom abstraction by a manganese catalyst.
- Electrical generation and detection of spin waves in a quantum Hall ferromagnet
Transport measurements are used to monitor the propagation of magnons in a graphene sample.
- Systemic control of legume susceptibility to rhizobial infection by a mobile microRNA
A microRNA made in the shoot regulates microbial nodulation in Lotus roots.
- Systematic discovery of natural CRISPR-Cas12a inhibitors
CRISPR-Cas12a inhibitors that block gene editing in human cells are identified.
- Discovery of widespread type I and type V CRISPR-Cas inhibitors
CRISPR-Cas12a inhibitors that block gene editing in human cells are identified.
Technical Comments
Erratum
From the AAAS Office of Publishing and Member Services
About The Cover
COVER Neurons of the brain find their places during development guided by internal programs and external interactions. This confocal microscopy image from a Drosophila larva shows the characteristic placement of neurons in the optic lobe. The neurons are organized in layers according to their birth order, with the color of each layer corresponding to its neurons' unique expression of transcription factors, as detected by immunofluorescence. This special issue highlights the behind-the-scenes forces and constraints that guide brain development. See page 170.
Image: Isabel Holguera, Claude Desplan laboratory