Research Article

The chromatin accessibility landscape of primary human cancers

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Science  26 Oct 2018:
Vol. 362, Issue 6413, eaav1898
DOI: 10.1126/science.aav1898

Article Information

vol. 362 no. 6413

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History: 
  • Received for publication August 22, 2018
  • Accepted for publication September 28, 2018

Author Information

  1. M. Ryan Corces1,*,
  2. Jeffrey M. Granja1,2,3,*,
  3. Shadi Shams1,
  4. Bryan H. Louie1,
  5. Jose A. Seoane2,4,5,
  6. Wanding Zhou6,
  7. Tiago C. Silva7,8,
  8. Clarice Groeneveld9,
  9. Christopher K. Wong10,
  10. Seung Woo Cho1,
  11. Ansuman T. Satpathy1,
  12. Maxwell R. Mumbach1,2,
  13. Katherine A. Hoadley11,
  14. A. Gordon Robertson12,
  15. Nathan C. Sheffield13,
  16. Ina Felau14,
  17. Mauro A. A. Castro9,
  18. Benjamin P. Berman7,
  19. Louis M. Staudt14,
  20. Jean C. Zenklusen14,
  21. Peter W. Laird6,
  22. Christina Curtis2,4,5,
  23. The Cancer Genome Atlas Analysis Network,
  24. William J. Greenleaf1,2,3,15,16,,
  25. Howard Y. Chang1,2,17,18,
  1. Corresponding author. Email: howchang{at}stanford.edu (H.Y.C.); wjg{at}stanford.edu (W.J.G.)
    1. 1Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
    2. 2Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
    3. 3Program in Biophysics, Stanford University School of Medicine, Stanford, CA 94305, USA.
    4. 4Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
    5. 5Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
    6. 6Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
    7. 7Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
    8. 8Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP CEP 14.040-905, Brazil.
    9. 9Bioinformatics and Systems Biology Laboratory, Polytechnic Center, Federal University of Paraná, Curitiba, PR CEP 80.060-000, Brazil.
    10. 10Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California–Santa Cruz, Santa Cruz, CA 95064, USA.
    11. 11Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    12. 12Canada’s Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
    13. 13Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
    14. 14National Cancer Institute, NIH, Bethesda, MD 20892, USA.
    15. 15Department of Applied Physics, Stanford University, Stanford, CA 94025, USA.
    16. 16Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
    17. 17Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA.
    18. 18Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
    1. * These authors contributed equally to this work.

    • The Cancer Genome Atlas Analysis Network collaborators and affiliations are listed in the supplementary materials.

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    Oct 201810304319448
    Nov 20188495100394134
    Dec 201814801043463