In DepthInfectious Diseases

Indonesian fatwa causes immunization rates to drop

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Science  09 Nov 2018:
Vol. 362, Issue 6415, pp. 628-629
DOI: 10.1126/science.362.6415.628

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  • MR Halal and MR Haram
    • Sunil Kumar Verma, Principal Scientist, CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500039, India

    The domestic pig (Sus scrofa) is a eutherian mammal and a member of the Cetartiodactyla order, a clade also shared by whales, hippos, camels, and ruminants such as cows and buffalos, sheeps and goats. Runinants such as Cows and Goats shared a common ancestor with pigs between 64.7 ± 2.6 million years (Myr) ago (1). The modern insight into the complete genome sequences of pig suggest that it share strong genetic similarities with other livestock including cow (2-4).

    A quick BLAST analysis of the protein sequence (UniProt accession Nnmber P00761) (5) of porcine origin trypsin enzyme in question suggests that this protein is 82% similar with E value 9e-142 to the comparable trypsin protein from Bos taurus i.e cow origin and 84% similar with E value 3e-144 to the comparable trypsin protein from Capra hircus i.e goat origin (accession number NP_001107199.1 and XP_005701320.1, respectively). Not only this, the major milk protein such as Kappa-casein from pig origin (UniProt accession number P11841) and Beta casien (UniProt accession number P39037) also share 54-68% similarities with comparable proteins present in cow and goat.

    According to the Islamic Ulema Council of Jakarta, if merely touching the virus producing cells with pig origin trypsin during tripsinization process of vaccine manufacturing can make the whole vaccine "Haram" then special care must be taken by the vaccine manufacturers who are now considering to make "Halal" vaccine by...

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    Competing Interests: None declared.