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An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

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Science  09 Nov 2018:
Vol. 362, Issue 6415, pp. 700-705
DOI: 10.1126/science.aap9310

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vol. 362 no. 6415 700-705

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History: 
  • Received for publication September 11, 2017
  • Resubmitted April 10, 2018
  • Accepted for publication September 19, 2018

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Author Information

  1. Xiangjun Chen1,
  2. Xiaolin Sun2,*,
  3. Wei Yang3,*,
  4. Bing Yang1,*,
  5. Xiaozhen Zhao2,
  6. Shuting Chen1,
  7. Lili He1,
  8. Hui Chen4,
  9. Changmei Yang1,
  10. Le Xiao1,
  11. Zai Chang3,
  12. Jianping Guo2,
  13. Jing He2,
  14. Fuping Zhang5,
  15. Fang Zheng6,
  16. Zhibin Hu7,
  17. Zhiyong Yang8,
  18. Jizhong Lou4,
  19. Wenjie Zheng9,
  20. Hai Qi10,
  21. Chenqi Xu11,
  22. Hong Zhang12,
  23. Hongying Shan13,
  24. Xu-jie Zhou12,
  25. Qingwen Wang13,
  26. Yi Shi14,15,
  27. Luhua Lai16,
  28. Zhanguo Li2,,
  29. Wanli Liu1,17,
  1. 1Ministry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  2. 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135), Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100044, China.
  3. 3School of Life Sciences, Tsinghua University, Beijing 100084, China.
  4. 4Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  5. 5Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  6. 6Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  7. 7Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  8. 8Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
  9. 9Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
  10. 10Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, Beijing 100084, China.
  11. 11State Key Laboratory of Molecular Biology, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
  12. 12Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China.
  13. 13Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China.
  14. 14CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.
  15. 15Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
  16. 16BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Peking-Tsinghua Center for Life Sciences at College of Chemistry and Molecular Engineering, Center for Quantitative Biology, Peking University, Beijing 100871, China.
  17. 17Beijing Key Lab for Immunological Research on Chronic Diseases, Beijing 100084, China.
  1. Corresponding author. Email: liulab{at}tsinghua.edu.cn (W.L.); li99{at}bjmu.edu.cn (Z.L.)
  1. * These authors contributed equally to this work.

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