Research Article

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

See allHide authors and affiliations

Science  16 Nov 2018:
Vol. 362, Issue 6416, eaat9528
DOI: 10.1126/science.aat9528

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Mitochondrial serine transporter identified

One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells. The transport of serine into mitochondria supplies most of the 1C units needed for biosynthesis. Kory et al. used a genetic screen to identify the long-sought-after mitochondrial serine transporter. Elucidating the key step of serine transport is important for our understanding of metabolism and has potential implications for cancer treatment.

Science, this issue p. eaat9528