Contents

30 November 2018
Vol 362, Issue 6418

About The Cover

Cover image expansion

COVER Structures of the actively degrading 26S proteasome show consecutive states of the ATPase motor with conserved tyrosine paddles (blue, green, and yellow clusters) arranged in a spiral staircase and pulling a protein substrate (yellow blocks) into a degradation chamber. The original conformational state is transparent, whereas the subsequent state is opaque. The data provide insights into how this member of the AAA+ family couples ATP hydrolysis with conformational changes to produce mechanical work. See eaav0725.
Illustration: V. Altounian/Science; Structural data: PDB IDs 6EF1 and 6EF3