Precision genome engineering

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Science  30 Nov 2018:
Vol. 362, Issue 6418, pp. 1015-1016
DOI: 10.1126/science.362.6418.1015-b

Genome editing through CRISPR-Cas systems has the potential to correct genetic mutations that occur in diseased cells, such as cancer cells. However, the ability to selectively activate CRISPR-Cas systems in diseased cells is important to ensure that gene editing only occurs where it is wanted. Zhu et al. developed a system whereby gene editing could be activated by a magnetic field, thus allowing spatial control. The use of nanomagnets in their system also improved transduction into target cells in tumor-bearing mouse models. This approach could potentially allow the translation of CRISPR-Cas systems into therapeutic agents.

Nat. Biomed. Eng. 10.1038/s41551-018-0318-7 (2018).

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