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Single-cell multiomics sequencing and analyses of human colorectal cancer

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Science  30 Nov 2018:
Vol. 362, Issue 6418, pp. 1060-1063
DOI: 10.1126/science.aao3791

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scTrio-seq identifies colon cancer lineages

To better design treatments for cancer, it is important to understand the heterogeneity in tumors and how this contributes to metastasis. To examine this process, Bian et al. used a single-cell triple omics sequencing (scTrio-seq) technique to examine the mutations, transcriptome, and methylome within colorectal cancer tumors and metastases from 10 individual patients. The analysis provided insights into tumor evolution, linked DNA methylation to genetic lineages, and showed that DNA methylation levels are consistent within lineages but can differ substantially among clones.

Science, this issue p. 1060