PerspectiveCANCER BIOLOGY

Metastases go with the flow

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Science  30 Nov 2018:
Vol. 362, Issue 6418, pp. 999-1000
DOI: 10.1126/science.aat9100

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Summary

To colonize distant organs and thus disseminate throughout the body, cancer cells and associated factors exploit several fluids for transport. Recently, circulating tumor cells (CTCs) were found to survive and exploit the inner biomechanics of the bloodstream to foster tumor metastasis (1, 2). Thus, in addition to using both the blood and lymphatic circulation as a means to travel throughout the body (35), the underlying forces allow CTCs to seed distant metastases. The contribution of fluids, particularly vascular flow mechanics, and physical constraints raises interesting questions about the biology of metastasis.