Cell Biology

Keeping a toehold on the matrix

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Science  07 Dec 2018:
Vol. 362, Issue 6419, pp. 1125-1126
DOI: 10.1126/science.362.6419.1125-d

Within our bodies, most tissues are organized in association with an extracellular matrix. The matrix keeps cells where they are supposed to be, and cells adhere to the matrix via integrin-containing cell adhesions. During mitosis, cells round up and release their tight association with the matrix. Lock et al. show that despite this, mitotic cells ensure that they retain their correct location by using a so-called reticular form of cell adhesion. A range of adherent cultured human cells was found to show this property. Reticular adhesions lack several components of classical adhesion complexes, including talin and actin. A key constituent of reticular adhesions is integrin β5, and a lack of it interfered with the retention of spatial localization through normal mitotic cell divisions.

Nat. Cell Biol. 20, 1290 (2018).

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