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A mechanistic classification of clinical phenotypes in neuroblastoma

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Science  07 Dec 2018:
Vol. 362, Issue 6419, pp. 1165-1170
DOI: 10.1126/science.aat6768

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A systematic look at a childhood tumor

Neuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well to treatment and some undergo spontaneous regression without treatment. Ackermann et al. sequenced more than 400 pretreatment neuroblastomas and identified molecular features that characterize the three distinct clinical outcomes. Low-risk tumors lack telomere maintenance mechanisms, intermediate-risk tumors harbor telomere maintenance mechanisms, and high-risk tumors harbor telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations.

Science, this issue p. 1165