Contents
14 December 2018
Vol 362, Issue 6420
Vol 362, Issue 6420
Special Issue
PsychENCODE
Introduction to special issue
Research Articles
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Ireland slashes peat power to lower emissions
Harvested from drained and denuded bogs, peat is more polluting than coal.
- Trump officials move to limit human fetal tissue research
NIH ordered staff scientists not to procure new tissue.
- U.N. HIV/AIDS agency assailed for culture of harassment
Independent panel calls for replacing executive director.
- Worries about Ebola outbreak grow, despite use of vaccine
DRC conflict hampers effort to track and contain virus.
- Space laser to map trees in 3D
GEDI data will yield maps of forest carbon and biodiversity.
- Human brain samples yield a genomic trove
Regulatory DNA takes center stage in search for mechanisms of disease.
- Bioelectronics that vanish in the body
Wire-free devices that dissolve could expand the use of electric pulses in medicine.
- Why modern humans have round heads
Neanderthal DNA points to genes that influence brain.
- Conferences score well on child care
Male-dominated disciplines lead the pack.
Feature
- Starry eyes
NASA is planning four of the largest space telescopes ever. But which one will fly?
Working Life
Letters
Books et al.
- Searching for the singularity
An embedded journalist tells the tale of an Earth-sized telescope that could provide the first image of a black hole
- Unlocking the science of success
A complexity expert reveals how social networks create recognition and acclaim
- A new hope for beating back cancer
Vivid portraits of patients, scientists, and physicians reveal the promise of immunotherapy
Policy Forum
Perspectives
- Reimagining the human
A human-centric worldview is blinding humanity to the consequences of our actions
- Printing nanomaterials in shrinking gels
Photopatterning of reactive sites in gels enables arbitrary patterning of nanoparticles
- Did maize dispersal precede domestication?
Unraveling the history of maize domesticates reveals a complex journey into South America
- Peanut allergen–specific antibodies go public
Characterizing peanut-specific antibodies may identify targets to treat food allergy
- Can witchweed be wiped out?
A potent stimulant induces parasitic plant germination that causes it to die
- Alzheimer's disease: The right drug, the right time
Lessons from failed clinical trials can improve the development of Alzheimer's disease–modifying therapies
Research Article
- Revealing hidden spin-momentum locking in a high-temperature cuprate superconductor
Spin- and angle-resolved photoemission spectroscopy reveals a rich spin texture in the cuprate Bi2212.
Reports
- Ultralow-loading platinum-cobalt fuel cell catalysts derived from imidazolate frameworks
Active cobalt sites and platinum-cobalt nanoparticles are combined in a highly active and durable oxygen reduction catalyst.
- 3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds
Direct writing of nanoscale 3D structures of metals and semiconductors operates with no geometry limitations.
- Evolution of a highly active and enantiospecific metalloenzyme from short peptides
A metal-binding peptide becomes a potent catalyst for ester hydrolysis.
- Observation of the geometric phase effect in the H + HD → H2 + D reaction
Precise experiments on an elementary reaction validate inclusion of a phase factor in adiabatic quantum mechanical simulations.
- Atmospheric 14C/12C changes during the last glacial period from Hulu Cave
Isotopic data from stalagmites provide a high-resolution radiocarbon record for the entire range of the 14C dating method.
- 1.9-million- and 2.4-million-year-old artifacts and stone tool–cutmarked bones from Ain Boucherit, Algeria
Stone tools and cutmarked bones indicate an early presence of human ancestors in North Africa.
- A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica
Chemical screening yields a strigolactone receptor agonist that may aid control in fields infected with a parasitic weed.
- High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes
Single-cell sequencing of IgE B cells from allergic individuals reveals surprising insights.
- Multiproxy evidence highlights a complex evolutionary legacy of maize in South America
A complex history of maize domestication arose from a secondary improvement center in the southwest Amazon.
About The Cover
COVER The human brain is the product of myriad molecular and genetic interactions. Here, a neon brain illustration represents individual genetic variability, some of which may lead to disease (denoted by dim or dark segments), as investigated by the PsychENCODE Consortium. This issue sheds light on neurogenetic and epigenetic variation in developing and adult neurotypical brains, as well as in schizophrenia, autism spectrum disorder, and bipolar disorder. See page 1262.
Illustration: V. Altounian/Science