Targeting brown fat to make less fat

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Science  21 Dec 2018:
Vol. 362, Issue 6421, pp. 1373-1374
DOI: 10.1126/science.362.6421.1373-b

Heat production by brown fat cells (shown) might reduce appetite.


Brown fat can release energy from food as heat instead of storing it and could thus help in battling obesity. Li et al. found that after a meal, brown fat in mice was stimulated to increase thermogenesis by direct action of the gut hormone secretin. The heat produced may be detected by the brain and thus induce a sense of satiety. This signaling relay may increase energy expenditure and decrease appetite, making it a potential target for therapies that attempt to control obesity.

Cell 175, 1561 (2018).

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