Human Genetics

Alzheimer's disease in admixed people

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Science  04 Jan 2019:
Vol. 363, Issue 6422, pp. 40
DOI: 10.1126/science.363.6422.40-b

Several genes have been identified that increase the risk of late-onset genetic disorders, such as Alzheimer's disease (AD). Specifically, the ApoE ε4 allele is associated with a higher risk of developing AD. However, individuals of African ancestry that carry this variant appear to be less prone to developing AD. Rajabli et al. examined AD cases and controls in admixed individuals of Puerto Rican and African-American descent and found that individuals who carried an African ApoE ε4 background had less risk of developing the disease. It seems the African variant of ApoE ε4 contains protective genetic variants.

PLOS Genet. 14, e1007791 (2018).

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