Roots of acne

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Science  04 Jan 2019:
Vol. 363, Issue 6422, pp. 40-41
DOI: 10.1126/science.363.6422.40-d

Most people experience a bout of acne at some stage in their life. For an unlucky few, the skin condition feels relentless and can evade treatment. Petridis et al. performed a DNA study of individuals with acne vulgaris and found that those affected share similar, but surprising, genetic mutations. Homing in on 15 regions of the genome, they identified a series of culprit genes that controlled hair growth and follicle formation. This discovery lends weight to the idea that hair follicle shape creates a milieu susceptible to bacterial colonization and inflammation.

Nat. Commun. 9, 5075 (2018).

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