T cells traffic at fever pitch

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Science  08 Feb 2019:
Vol. 363, Issue 6427, pp. 596
DOI: 10.1126/science.363.6427.596-c

Fever is an evolutionarily conserved response triggered by injury and infection that promotes survival. But the mechanisms underlying this protective effect are not well understood. High fever (40°C) in mice induces the expression of various heat shock proteins, including Hsp90. Lin et al. report that Hsp90 promotes T cell adhesion and transmigration by binding to and activating α4 integrins. If the α4 integrin–binding motif is mutated in mice, fever-induced T cell trafficking is inhibited and bacterial clearance impaired. Possibly, the trafficking of other immune cells is similarly affected by this signaling axis.

Immunity 50, 137 (2019).

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