Cell Biology

Chromosome axis organization

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Science  15 Feb 2019:
Vol. 363, Issue 6428, pp. 704
DOI: 10.1126/science.363.6428.704-b

The chromosome axis is a meiosis-specific structure that is essential for proper chromosome pairing and meiotic recombination. It is conserved among all eukaryotes; however, the key axis protein components are evolutionarily divergent among different species. West et al. characterized axis proteins in baking yeast, a mustard plant, and human. Although these proteins have little sequence homology, they all form filaments from tetrameric units and recruit key players that mediate downstream meiotic recombination. This common assembly feature ensures that the architecture of the meiotic-chromosome axis is highly conserved across fungi, mammals, and plants.

eLife 8, e40372 (2019).

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