Muscle Regeneration

Making more youthful muscle

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Science  22 Feb 2019:
Vol. 363, Issue 6429, pp. 832
DOI: 10.1126/science.363.6429.832-c

Aging reduces the body's ability to regenerate. The myogenic potential of muscle stem cells (MuSCs) is a prime example. Recent work shows that some factors that allow us to bounce back after injury include extracellular signals from the stem cell niche. Lukjanenko et al. show that MuSC dysfunction with aging is a result of the loss of matricellar WNT1 inducible signaling pathway protein 1 (WISP1) from fibro-adipogenic progenitors (FAPs). When WISP1 is secreted from FAPs, the Akt pathway is activated along with asymmetric MuSC cell division. Eliminating mouse WISP1 results in defective myogenesis with reduced MuSCs. By contrast, injecting aged mice with WISP1 rescues MuSC function. By identifying the cells and cell-secreted factors that support repair, it should be possible to generate more youthful muscle.

Cell Stem Cell 10.1016/j.stem.2018.12.014 (2019).

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