Unblocking the brain

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Science  01 Mar 2019:
Vol. 363, Issue 6430, pp. 942-943
DOI: 10.1126/science.363.6430.942-g

Although cerebral blood flow reductions have been observed in Alzheimer's disease and linked to impaired cognition, the precise mechanism is unclear. We know that circulating cells, such as neutrophils, can block brain capillaries and reduce blood flow in the cortex. Cruz Hernández et al. used in vivo microscopy in an Alzheimer's disease mouse model to investigate this phenomenon. They injected mice with a neutrophil-specific antibody and observed a direct reduction in the amount of neutrophils that stuck to and blocked the capillaries in the brain. This, in turn, increased cerebral blood flow and enhanced memory performance in these mice.

Nat. Neurosci. 10.1038/s41593-018-0329-4 (2019).

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