Research Article

Acoel genome reveals the regulatory landscape of whole-body regeneration

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Science  15 Mar 2019:
Vol. 363, Issue 6432, eaau6173
DOI: 10.1126/science.aau6173

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Acoel-regeneration regulatory landscapes

Some animals, including some types of worms, can undergo whole-body regeneration and replace virtually any missing cell type. Gehrke et al. sequenced and assembled the genome of Hofstenia miamia, a regenerative acoel worm species (see the Perspective by Alonge and Schatz). They identified a variable motif corresponding to regulation of the early growth response (egr) gene that was involved in regeneration. RNA interference experiments and validation in a second species showed that the protein Egr is a pioneer factor that stimulates regeneration.

Science, this issue p. eaau6173; see also p. 1152